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    Association details:
    Biomarker:FGFR expression
    Cancer:Cholangiocarcinoma
    Drug:PD173074 (Tyrosine kinase inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Cancers (Basel)
    Title:

    Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma

    Published date:
    04/28/2023
    Excerpt:
    Here we demonstrate aberrant FGFR expression in CCA samples using bioinformatics and further confirm phosphorylated-FGFR expression in paraffinised CCA tissues using immunohistochemistry….Furthermore, CCA cell lines with FGFR expression were sensitive to a selective pan-FGFR inhibitor, PD173074...
    DOI:
    https://doi.org/10.3390/cancers15092528