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    Association details:
    Biomarker:FGF19 overexpression
    Cancer:Hepatocellular Cancer
    Drug:fisogatinib (BLU-554) (FGFR4 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    New
    Source:
    Cancer Discov
    Title:

    First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma

    Excerpt:
    Fisogatinib elicited clinical responses in patients with tumor FGF19 overexpression in advanced HCC.
    DOI:
    10.1158/2159-8290.CD-19-0555