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Association details:
Evidence:
Evidence Level:
Resistant: C4 – Case Studies
New
Source:
Title:

FBXW7 Mutations in Patients with Advanced Cancers: Clinical and Molecular Characteristics and Outcomes with mTOR Inhibitors

Excerpt:
Ten patients were treated on a protocol containing an mTOR inhibitor, with a median time to treatment failure of 2.8 months (range, 1.3–6.8)...One patient with liver cancer (fibrolamellar subtype) continues to have a prolonged stable disease for 6.8+ months...In patients with advanced cancers, somatic mutations in FBXW7 usually occur with other simultaneous molecular aberrations, which can contribute to limited therapeutic efficacy of mTOR inhibitors...Characteristics of 18 patients with FBXW7 mutation-positive tumors.
DOI:
10.1371/journal.pone.0089388