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Association details:
Biomarker:
FBXW7 mutation
Cancer:
Non Small Cell Lung Cancer
Drug:
Stivarga (regorafenib)
(
Multi-tyrosine kinase inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Theranostics
Title:
Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer
Published date:
07/09/2020
Excerpt:
FBW7 mutations might be a potential biomarker predicting for response to the regorafenib/Mcl-1 inhibitor combination.
DOI:
10.7150/thno.45363
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