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Association details:
Biomarker:FAT4 mutation
Cancer:Non Small Cell Lung Cancer
Drug Class:Immunotherapy
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Title:

Prognostic and Immunological Role of FAT Family Genes in Non-Small Cell Lung Cancer

Published date:
02/25/2022
Excerpt:
...the relationship between FAT1/2/3/4 mutations and efficacy of immunotherapy was explored in the Hellmann cohort consist of patients with NSCLC....In this cohort, FAT4 mutations were significantly associated with better BOR rate (Figure 7B, χ2 = 4.723, P = .029), but not PFS (Figure 7A, P > .05) and DCB rates (Figure 7C, P > .05).
DOI:
https://doi.org/10.1177/10732748221076682