We reported a 44-year-old woman with non-viral HCC...A truncating mutation FANCA p.Q1307fs was also observed. The tumor was microsatellite stable and had low tumor mutational burden of 4.5 muts/Mb….the patient started to use olaparib combined with low-dose cisplatin...follow-up CT scan showed stable disease. Her tumor did not progress until December 2020 with a progression-free survival of 12 months.