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Association details:
| Biomarker: | FAM83D overexpression |
|---|---|
| Cancer: | Pancreatic Adenocarcinoma |
| Drug: | gemcitabine (DNA synthesis inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Fam83D promotes tumorigenesis and gemcitabine resistance of pancreatic adenocarcinoma through the Wnt/ß-catenin pathway
Published date:
02/11/2021
Excerpt:
Fam83D was overexpressed in PDAC and associated with clinical stage, metastatic status and survival rates of PDAC patients…Fam83D KD enhanced the sensitivity of PDAC cells to GEM in vitro and in vivo. On the contrary, Fam83D overexpression displayed reverse effects on PDAC cells. Moreover, the Wnt/β-catenin inhibitor abolished the effects of Fam83D overexpression in PDAC cells.
DOI:
10.1016/j.lfs.2021.119205