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Association details:
| Biomarker: | EZH2 Y646 |
|---|---|
| Cancer: | Melanoma |
| Drug: | GSK2816126 (EZH2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes
Excerpt:
The EZH2Y646 mutant cell lines were the most sensitive to GSK126 inhibition ranging from 3.2–8.0 μM...
DOI:
10.18632/oncotarget.4809
