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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia

Excerpt:
EBF1-PDGFRB expression (Figure 7A) conferred growth factor independence and resulted in significantly faster proliferation compared to Ba/F3 cells expressing the most common PDGFRB rearrangement, ETV6-PDGFRB (Figure 7B–C). Importantly, cytokine-independent proliferation was inhibited by imatinib (Figure 7B–C), the ABL1 and Src inhibitor dasatinib, and the multi-kinase inhibitor dovitinib (Figure S7A). Accordingly, imatinib treatment reduced phosphorylation of the PDGFRB receptor, with no change in total PDGFRB expression (Figure S7B).
DOI:
https://dx.doi.org/10.1016%2Fj.ccr.2012.06.005