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Association details:
| Biomarker: | ETV6-FLT3 fusion |
|---|---|
| Cancer: | Juvenile Myelomonocytic Leukemia |
| Drug: | Xospata (gilteritinib) (Multi-tyrosine kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ETV6-FLT3-positive myeloid/lymphoid neoplasm with eosinophilia presenting in an infant: an entity distinct from JMML
Published date:
04/13/2021
Excerpt:
...8-month-old infant who presented with clinical features similar to those of juvenile myelomonocytic leukemia (JMML) but who was diagnosed with MLN-Eo driven by an ETV6-FLT3 fusion...Treatment with the type I inhibitor gilteritinib resulted in complete immunophenotypic and cytogenetic remission.
DOI:
10.1182/bloodadvances.2020003699
