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Association details:
| Biomarker: | ESR1 mutation |
|---|---|
| Cancer: | Breast Cancer |
| Regimen: | (5-fluorouracil + cyclophosphamide + epirubicin) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Risk for relapse and death after adjuvant chemotherapy associated with SNPs in patients with breast cancer - A retrospective study
Published date:
01/01/2022
Excerpt:
For the women breast cancer (BC) patients included in this retrospective study, the first line of systemic treatment in adjuvant modality for breast cancer (BC) after surgery was fluorouracil, epirubicin and cyclophosphamide (FEC)....Two SNPs in the Estrogen hormone receptor gene ESR1 and the apoptosis execution gene Caspases 9 (Casp9) were found to be associated with a higher risk of relapse and death.
DOI:
10.1016/j.ctarc.2021.100505
