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    Association details:
    Biomarker:ERVE-4 expression
    Cancer:Clear Cell Renal Cell Carcinoma
    Drug:Opdivo (nivolumab) (PD1 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    AACR 2020
    Title:

    Expression of T-cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma

    Published date:
    11/20/2020
    Excerpt:
    ERVE4 expression was associated with increased DRR and longer PFS in nivo-treated patients.
    DOI:
    10.1158/1078-0432.CCR-20-3084