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Association details:
| Biomarker: | ERBB3 expression |
|---|---|
| Cancer: | Lung Cancer |
| Drug: | DB-1310 (Topoisomerase I inhibitor, HER3-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1884 / 23 - DB-1310, a novel Her3 targeting antibody-drug conjugate, exhibits therapeutic efficacy for solid tumors
Published date:
03/15/2023
Excerpt:
In vitro, DB-1310 exhibited cytotoxicity in a panel of Her3- expression human breast cancer and lung cancer cell lines….Tumor regression was observed in a NSCLC patient-derived xenograft model with EGFR mutation under DB-1310 treatment.
