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Association details:
| Biomarker: | ERBB3 expression |
|---|---|
| Cancer: | Endometrial Cancer |
| Drug: | lapatinib (EGFR inhibitor, HER2 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Abstract LB-326: The role of HER3 in HER2-amplified cancers other than breast cancers
Published date:
05/15/2020
Excerpt:
Lapatinib induced apoptosis correlated with HER3 activation. Tumor growth was reduced upon HER3 knockdown in HER2-amplified cancers other than breast cancers, particularly cancers with constitutive HER3 phosphorylation. Many HER2-amplified cancers of the breast (HCC1569, HCC1954, HCC1419, UACC732, SUM190), bladder (CLS-439), stomach (N87, OE19), esophagus (TE4, KYSE410), lung (Calu3), and endometrium (USPC-ARC1, USPC-ARC2) showed HER3 activation.....
DOI:
10.1158/1538-7445.AM2020-LB-326
