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Association details:
| Biomarker: | ER T594T |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | tamoxifen (Estrogen receptor antagonist) |
| Direction: | Resistant |
Evidence:
Source:
Title:
94P - Coexpression of PI3K/Akt signaling components and breast stem cells markers: Potential contributions in resistance to tamoxifen treatment
Published date:
09/14/2020
Excerpt:
Flow cytometry was used to evaluate the expression levels of CD326+CD44+CD24-/low, p-Akt473, PTEN, IGFR1 (CD221) and their combinations in fresh frozen breast cancer samples from 59 patients who developed distant metastasis....The AA mutant genotypes of ESR1 rs2228480 were more frequent among the TR group than in TS patients (P=0.040). Kaplan–Meier analysis showed a poorer clinical outcome for patients of the mutant genotype of ESR1 rs2228480 (log-rank P=0.043).
