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Association details:
| Biomarker: | ER positive |
|---|---|
| Cancer: | HER2 Negative Breast Cancer |
| Drug: | MEN2312 (KAT6 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ISM5043, a novel, selective KAT6 inhibitor for the treatment of advanced and refractory ER+ breast cancer
Published date:
12/02/2023
Excerpt:
Here, we evaluated ISM5043, a novel, small molecule KAT6 inhibitor for anti-tumor effects in ER+/HER2- breast cancer cell lines and animal models.In the ZR-75-1 (ER+, HER2-) xenograft model, ISM5043 demonstrated robust and dose dependent anti-tumor activity, as monotherapy, with Tumor Growth Inhibition (TGI) between 80~110% at doses ranging from 0.3 to 10 mg/kg, QD….