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Association details:
| Biomarker: | ER positive |
|---|---|
| Cancer: | Estrogen Receptor Positive Breast Cancer |
| Drug: | ZEN-3694 (BET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Combination of ZEN-3694 with CDK4/6 inhibitors reverses acquired resistance to CDK4/6 inhibitors in ER-positive breast cancer
Published date:
08/12/2021
Excerpt:
...we evaluated the effect of ZEN-3694 on the proliferation of ER+ breast cancer cell lines (Fig. 2). ZEN-3694 inhibited the proliferation of several ER+ cell lines at low micromolar concentrations and importantly had similar antiproliferative effects in wild type and CDK4/6i resistant cell lines, which indicates that ZEN-3694 can potentially alleviate the developed resistance to these agents...
