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Association details:
| Biomarker: | ER positive |
|---|---|
| Cancer: | Estrogen Receptor Positive Breast Cancer |
| Drug: | TEQ103 (Cell death stimulant, Selective estrogen receptor activator, Unfolded protein response activator) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
522 / 22 - Selective estrogen receptor a-UPR activators (SERA): a novel class of small molecules that eradicate estrogen receptor positive tumors
Published date:
03/15/2023
Excerpt:
In the MCF-7 ERα+ breast cancer xenograft model, once weekly IV injections of SERA2 at 10mg/kg cause durable, complete tumor regression, and SERA2 also has impressive activity in a challenging-to-treat PDX model that is resistant to fulvestrant and tamoxifen.
