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Association details:
| Biomarker: | ER positive |
|---|---|
| Cancer: | Estrogen Receptor Positive Breast Cancer |
| Drug: | tamoxifen (Estrogen receptor antagonist) + trefoil factor 3 protein (TFF3) (Mucoprotein stimulant) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Small molecule inhibition of TFF3 overcomes tamoxifen resistance and enhances taxane efficacy in ER+ mammary carcinoma
Published date:
10/17/2023
Excerpt:
Synergistic effects of AMPC and tamoxifen were demonstrated in ER + MC cells and AMPC was observed to improve tamoxifen efficacy in tamoxifen-sensitive cells and to re-sensitize cells to tamoxifen in tamoxifen-resistant ER + MC in vitro and in vivo.