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Association details:
| Biomarker: | ER positive |
|---|---|
| Cancer: | Estrogen Receptor Positive Breast Cancer |
| Drug: | tamoxifen (Estrogen receptor antagonist) + amitriptyline (Norepinephrine reuptake inhibitor, Serotonin reuptake inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
P3-07-19 Anti-depressant Amitriptyline Augments the Efficacy of Tamoxifen in ER positive breast cancer
Published date:
11/22/2022
Excerpt:
Amitriptyline treatment blocked the growth of ER+ BC growth in pre-clinical orthotopic xenograft model of breast cancer. Importantly, Amitriptyline treatment sensitized ER+ BC to TAM, showing highly synergistic effects….Our study establishes potential of Amitriptyline as a repurposable drug as safe and robust treatment option for ER+ patients, either as a monotherapy or in combination.