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Association details:
| Biomarker: | ER positive |
|---|---|
| Cancer: | Estrogen Receptor Positive Breast Cancer |
| Drug: | tamoxifen (Estrogen receptor antagonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The effect of curcumin and piperine on tamoxifen metabolism in patients breast cancer 'the ELDORADO study' Het effect van kurkuma en piperine op het metabolisme van tamoxifen bij patiënten met borstkanker 'de ELDORADO studie'
Excerpt:
...Histological or cytological confirmed diagnosis of estrogen receptor positive breast cancer in patients with an indication for tamoxifen treatment. ...
Trial ID:
Source:
Title:
Clinical study of TCM 'Liangxue Shugan fang' in the treatment of postoperative estrogen receptor-positive breast cancer patients
Excerpt:
...By pathology or cytology and immunohistochemistry diagnosed estrogen receptor-positive breast cancer patients; 2. ...
Trial ID:
More C2 evidence
Source:
Title:
A window of opportunity study to assess the biological effects of progesterone in premenopausal ER-positive, PgR-positive early breast cancer
Excerpt:
...• Women 16 years of age and above• New diagnosed histologically confirmed breast cancer• Premenopausal as defined by the following criteria: o gonadotrophin levels (luteinizing hormone and follicle stimulating hormone) and oestradiol levels within the local laboratory’s reference range for premenopausal females• Ability to provide menstrual cycle information• ER positive (Allred ≥3)• PgR positive (Allred ≥3)• HER2 negative (IHC 1+ or 2+ and HER2/CEP17 ratio of cceptable methods of contraception.b. ...
Trial ID:
Source:
Title:
Prevalence of Genetic Polymorphisms in Genes Coding for Tamoxifen Metabolising Enzymes
Excerpt:
...- Breast cancer should be considered as oestrogen receptor positive by the clinician using immunohistochemistry readings as is standard procedure for local pathologist...
Trial ID:
Source:
Title:
An Observational Study to Assess Response to Tamoxifen in Breast Cancer Patients
Excerpt:
...- Breast cancer should be considered as oestrogen receptor positive by the clinician using immunohistochemistry readings as is standard procedure for local pathologist...
Trial ID:
Source:
Title:
Evaluation of Endocrine Therapy Effects of Host Immunity in Early Stage Breast Cancer
Excerpt:
...Histologically documented estrogen receptor positive adenocarcinoma of the breast that is (any progesterone status allowed):...
Trial ID:
Less C2 evidence
Source:
Title:
Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant ERa expression and proliferation in luminal primary and metastatic breast cancer cells
Published date:
04/13/2022
Excerpt:
Data revealed that ERα-positive BC cell lines are significantly more sensitive to all the CHK1 inhibitors analyzed (except for SB) than ERα-negative BC cell lines (Fig. 5A). The sensitivity to ATR inhibition is higher in ERα-positive than in the ERα-negative BC cell lines while no differences have been observed for BC cell lines treated with the ATM inhibitor KU. ERα-positive BC cell lines show increased sensitivity to Tam with respect to the ERα-negative BC cell lines (Fig. 5A’).
DOI:
10.1186/s13046-022-02360-y
Source:
Title:
Breast cancer cells gain enhanced susceptibility to Stat3 inhibitors during their response to endocrine treatment
Published date:
05/28/2021
Excerpt:
Estrogen receptor positive MCF7 cells were treated with 10-6M 4-hydroxy-Tamoxifen until resistance had developed....RPPA proteomic analysis identified a biphasic response of MCF7 cells to Tamoxifen…
