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    Association details:
    Biomarker:ER positive
    Cancer:Estrogen Receptor Positive Breast Cancer
    Drug:SB02024 (PI3K inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Biochem Pharmacol
    Title:

    VPS34-IN1 induces apoptosis of ER+ breast cancer cells via activating PERK/ATF4/CHOP pathway

    Published date:
    06/09/2023
    Excerpt:
    VPS34-IN1 significantly inhibited the growth of ER+ breast cancer cells at 48 h under a light microscope….Our results revealed that VPS34-IN1 inhibited the viability of ER+ breast cancer cells in vitro and in vivo...
    DOI:
    https://doi.org/10.1016/j.bcp.2023.115634