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Association details:
| Biomarker: | ER overexpression |
|---|---|
| Cancer: | HER2 Positive Breast Cancer |
| Drug Class: | Aromatase inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients
Excerpt:
...254 patients with ER-positive primary breast cancer randomised to receive 2-week presurgical AI...High baseline ESR1 expression associated with better AI response in HER2+ tumours but not HER2- tumours.
DOI:
10.1186/s13058-019-1223-z.
