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Association details:
| Biomarker: | ER D538G |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | AZD9496 (Selective estrogen receptor degrader) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models
Excerpt:
AZD9496 bound and downregulated clinically relevant ESR1 mutants in vitro and inhibited tumor growth in an ESR1-mutant patient-derived xenograft model that included a D538G mutation.
DOI:
10.1158/0008-5472
