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Association details:
| Biomarker: | EPAS1 overexpression |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Drug: | sorafenib (Multi-tyrosine kinase inhibitor, pan-RAF inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Role of HIF-1a on prognosis value and acquisition of sorafenib chemoresistance in hepatocarcinoma
Published date:
05/28/2021
Excerpt:
...we evaluated the role of HIF-1α in prognosis of HCC patients and in the sorafenib resistance development in an in vitro HCC model….HIF-1α silencing reduced resistant cells viability, relating HIF-1α overexpression with its prosurvival ability….
Source:
Title:
Identification of prognostic value of HIF-2a and a potential role in sorafenib resistance development in hepatocarcinoma
Published date:
05/28/2021
Excerpt:
Along with the prognostic value of HIF-2α, we also evaluated in vitro its role in sorafenib resistance acquisition. Resistant cells showed increased growth rate...HIF-2α overexpression is related to...the prosurvival ability of sorafenib resistant cells, remarking the potential role of HIF-2α as a useful biomarker and therapeutic target in HCC.
