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Association details:
| Biomarker: | ENO1 elevation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug Class: | Immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
179P - Integrative analysis revealed the signature of cancer stem cells and its immunosuppressive role in lung adenocarcinoma
Published date:
03/23/2023
Excerpt:
In our in-house cohort of 57 samples from 17 non-small cell lung cancer (NSCLC) patients treated with immunotherapy, the serum proteomics data revealed that ENO1 was significantly higher in non-responders (p = 0.0023) and its level increased as disease progressed (p = 0.005)...This study characterized and thoroughly elucidated CSCs, through integrative analyses of multi-omics data, identifying ENO1 as a novel serum biomarker for predicting immunotherapeutic outcome in NSCLC.
