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Association details:
| Biomarker: | ENG elevation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | pemetrexed (Thymidylate synthase inhibitor, THF dehydrogenase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Plasma Endoglin is Associated with Favorable Outcome for Pemetrexed-Based Therapy in Advanced Non-Small Cell Lung Cancer
Published date:
12/22/2021
Excerpt:
High ENG concentration was correlated with improved progression-free survival (hazard ratio [HR]: 0.52, 95% confidence interval [CI]: 0.31– 0.86, p < 0.01) and overall survival (HR: 0.55, 95% CI: 0.32– 0.94, p < 0.05) in patients treated with Pem-C, and the ENG level was an independent factor in our cohort (HR: 0.54, 95% CI: 0.33– 0.89, p < 0.05). ENG concentration in Pem-C responders also significantly increased at the time of best response (p < 0.05)...high ENG concentration in the blood is correlated with favorable PFS and OS after Pem-C in patients with advanced non-squamous NSCLC, and ENG level is an independent factor for finding Pem-C responders.
Secondary therapy:
Chemotherapy
DOI:
https://doi.org/10.2147/CMAR.S338957