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Association details:
Biomarker:
EML4-ALK L1196M
Cancer:
Non Small Cell Lung Cancer
Drug:
Xalkori (crizotinib)
(
ALK inhibitor
)
Direction:
Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
New
Source:
J Thorac Oncol
Title:
Heterogeneity of Genetic Changes Associated with Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancer
Excerpt:
ALK Mutations Confer Resistance to Crizotinib.
DOI:
10.1097/JTO.0b013e318283dcc0
Trial ID:
PROFILE 1001
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