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Association details:
| Biomarker: | EML4-ALK G1269A |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Zykadia (ceritinib) (ALK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer
Excerpt:
Ceritinib has demonstrated impressive activity in the clinic in crizotinib-resistance patients...These findings are consistent with preclinical studies presented in this manuscript demonstrating the activity of ceritinib against G1269A and S1206Y crizotinib-resistance mutations, and its lack of potency against the G1202R mutation.
DOI:
10.1158/2159-8290.CD-13-0846
