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Association details:
| Biomarker: | EML4-ALK F1174C |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Zykadia (ceritinib) (ALK inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer
Excerpt:
However, we observed that ceritinib did not overcome two crizotinib-resistant ALK mutations, G1202R and F1174C, and one of these mutations were identified in 5 out of 11 biopsies from patients with acquired resistance to ceritinib.
DOI:
10.1158/2159-8290.CD-13-0846
