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Association details:
Evidence:
Evidence Level:
Sensitive: C4 – Case Studies
Title:

P84.18 - Primary Resistance to Brigatinib in a Patient with Lung Adenocarcinoma Harboring ALK G1202R Mutation and LIPI-NTRK1 Rearrangement

Published date:
01/12/2021
Excerpt:
A 43-year-old woman....stage IVa (T2bN2M1b) lung adenocarcinoma...Three different mutation type were detected, including the classical EML4-ALK fusion, the ALK G1202R acquired resistance mutation and a new fusion form of NTRK rearrangement (LIPI-NTRK1)...Ultimately, This patient had a progression-free survival of 7 months with crizotinib but of only one month with brigatinib treatment.