^
Association details:
| Biomarker: | EGFRvIII mutation |
|---|---|
| Cancer: | Glioblastoma |
| Drug Class: | EGFRvIII-targeted CAR-T immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma
Excerpt:
EGFRvIII-directed CAR T cells were also able to control tumor growth in xenogeneic subcutaneous and orthotopic models of human EGFRvIII(+) glioblastoma.
DOI:
10.1126/scitranslmed.aaa4963
