^
    Back
    Association details:
    Biomarker:EGFR wild-type
    Cancer:Non Small Cell Lung Cancer
    Drug:Loqtorzi (toripalimab-tpzi) (PD1 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: B - Late Trials
    Source:
    ESMO 2023
    Title:

    1265P - Toripalimab plus chemotherapy as neoadjuvant treatment for resectable stage IIB-IIIB NSCLC (RENAISSANCE study): A single-arm, phase II trial

    Published date:
    10/16/2023
    Excerpt:
    Pts with resectable stage IIB-IIIB, wildtype EGFR/ALK NSCLC were eligible. All pts received 2-4 cycles of toripalimab (240mg, q3w) plus double platinum-based chemotherapy….Neoadjuvant toripalimab plus chemotherapy resulted in promising MPR rate and manageable toxicity for patients with resectable stage IIB-IIIB NSCLC.
    Secondary therapy:
    Chemotherapy
    Trial ID:
    Renaissance
    Evidence Level:
    Sensitive: B - Late Trials
    Source:
    J Clin Oncol
    Title:

    Toripalimab Plus Chemotherapy for Patients With Treatment-Naive Advanced Non–Small-Cell Lung Cancer: A Multicenter Randomized Phase III Trial (CHOICE-01)

    Published date:
    10/07/2022
    Excerpt:
    Patients (N = 465) with treatment-naive, advanced NSCLC without EGFR/ALK mutations were randomly assigned 2:1 to receive toripalimab 240 mg (n = 309) or placebo (n = 156) once every 3 weeks in combination with chemotherapy...Toripalimab plus chemotherapy significantly improves PFS and OS in patients with treatment-naive advanced NSCLC
    Secondary therapy:
    Chemotherapy
    DOI:
    10.1200/JCO.22.00727
    Trial ID:
    CHOICE-01
    Evidence Level:
    Sensitive: C2 – Inclusion Criteria
    New
    Source:
    clinicaltrials.gov
    Title:

    Glumetinib Combined With Toripalimab in the Treatment of Relapsed or Metastatic Non-small Cell Lung Cancer.

    Excerpt:
    ...Subsubjects with histologically or cytologically confirmed NSCLC, clinically diagnosed as locally advanced (stage IIIB or IIIC) and stage IV NSCLC (according to AJCC 8th edition staging), EGFR wild-type, negative for ALK and ROS1 rearrangement, and...
    Trial ID:
    CT32
    Evidence Level:
    Sensitive: C2 – Inclusion Criteria
    New
    Source:
    clinicaltrials.gov
    Title:

    Neoadjuvant Toripalimab Plus Platinum-based Doublet for Stage III Non-small Cell Lung Cancer

    Excerpt:
    ...Tumor should be EGFR wild-type or EML4-ALK negative; 3....
    Trial ID:
    NeoTPD01
    Less C2 evidence
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    IASLC-WCLC 2022
    Title:

    WS08.22 - Neoadjuvant Toripalimab Combination in Patients with Stage IIB-IIIB NSCLC: A Single-arm, Phase 2 Trial (Renaissance Study)

    Published date:
    07/12/2022
    Excerpt:
    39 pts underwent resection (median interval between neoadjuvant treatment and surgery: 67 days, IQR: 39-113). 25 pts (25/39, 64.1%) achieved MPR, including 20 pts (20/39, 51.3%) with pCR. R0 resection was achieved in all 39 pts (100%). 29 pts underwent surgery with cN2/N1 at baseline (29/31, 93.5%) achieved nodal downstaging. 49 pts finished the treatment schedule and radiological reassessment, ORR was 85.7% (42/49). Neoadjuvant toripalimab plus platinum-based doublet is a promising, tolerable and effective treatment for pts with stage IIB-IIIB NSCLC.
    Secondary therapy:
    cisplatin
    Trial ID:
    Renaissance