We report a case of EGFR wild-type and ALK-negative lung adenocarcinoma...After approval from the institutional ethics committee, she underwent concurrent oral apatinib (500 mg/day)...Three weeks later, neurologic symptoms entirely ceased and a partial response (PR) for the BMs with near-complete resolution of peritumoral brain edema was achieved. Chest CT performed at the same time and showed shrinkage of the lung primary with a PR.