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Association details:
| Biomarker: | EGFR T854A |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | gefitinib (EGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Acquired Resistance to EGFR Kinase Inhibitors Associated with a Novel T854A Mutation in a Patient with EGFR-Mutant Lung Adenocarcinoma
Excerpt:
...at position 854 (T854A), was identified in one patient with a drug-sensitive EGFR L858R-mutant lung adenocarcinoma after long-term treatment with tyrosine kinase inhibitors...Surrogate kinase assays show that the EGFR T854A mutation abrogates the inhibition of tyrosine phosphorylation by erlotinib...Such resistance seems to be overcome by a new irreversible dual EGFR/HER2 inhibitor, BIBW 2992….The T854A mutation is the second reported second-site acquired resistance mutation that is within contact distance of gefitinib and erlotinib.
DOI:
10.1158/1078-0432.CCR-08-0151
