In 18 pts with T790 mutation, mPFS of 10 pts in anlotinib and 8 pts in placebo group were 3.27 vs. 0.83 month (P< 0.0001, HR = 0.044)...The PFS of 7 pts in anlotinib and 3 pts in placebo arm with previous osim treatment were 4.00 vs. 0.40 month (P= 0.0076, HR = 0.108), and OS were 10.10 vs. 2.20 month (P= 0.03, HR = 0.071), respectively....Anlotinib revealed an optimistical trend in PFS than placebo in pts with T790 mutation or resistance to osim.