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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers

Published date:
03/19/2021
Excerpt:
...co-treatment with PI3K pathway inhibitors was able to partially re-sensitise cells to osimertinib in both 2D (Fig. 5b) and 3D cultures (Supplementary Fig. 7c). Similar findings were observed in the PC9-T790M and HCC827 cell line models, where knock-in of the PIK3CAm resulted in resistance to osimertinib, which could be partially rescued by a co-treatment with PI3K pathway inhibitors (Fig. 5b), offering possible therapeutic strategies to combat TKI resistance driven by PIK3CA mutations.
DOI:
10.1038/s41467-021-22057-8