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    Association details:
    Biomarker:EGFR S464L
    Cancer:Non Small Cell Lung Cancer
    Drug:Tagrisso (osimertinib) (EGFR inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C4 – Case Studies
    Source:
    Transl Lung Cancer Res
    Title:

    ctDNA analysis reveals different molecular patterns upon disease progression in patients treated with osimertinib

    Published date:
    03/13/2020
    Excerpt:
    Curiously, we detected the p.S464L mutation in the EGFR gene in a patient who was treated with cetuximab plus afatinib prior to osimertinib therapy….Table 2 Molecular alterations detected in ctDNA upon progression to osimertinib treatment.
    DOI:
    10.21037/tlcr.2020.04.01