...For patients with recurrence and metastasis after surgery, the time from the last postoperative adjuvant chemotherapy should be >=4 weeks; radiotherapy: the time from the last chest radiotherapy should be more than 12 weeks; the time from other parts of the radiotherapy should be more than 2 weeks; the time from the last operation more than 4 weeks (Except for thoracic or pericardial drainage); thoracic or pericardial drainage: more than 2 weeks or longer from the date of drainage; 2.Patients with malignant pleural effusion or pericardial effusion (in principle, cytological examination should be performed, but even if there is no malignant cytological examination, patients with imaging and clinical evidence of malignant pleural effusion or malignant pericardial effusion can also be used According to this standard, it is deemed qualified); 3.EGFR mutation positive; 4.Patients can take drugs orally; 5.Have one or more measurable lesions in accordance with the RECIST 1.1 standard; 6.ECOG score 0~2 points; 7.Aged 18 to 75 years; 8.The main organs are functioning normally, that is, they meet the following standards: (1)The standard of blood routine examination should meet: 1)ANC>=1.5x10^9/L; 2)PLT>=100x10^9/L; 3)Hb>=100g/L; (No blood transfusion or blood products, no correction with G-CSF and other hematopoietic stimulating factors within 14 days) (2)The biochemical inspection must meet the following standards: 1)TBIL=50ml/min (Cockcroft-Gault formula). ...