...1) Subjects voluntarily joined the study and signed informed consent; 2) Male or female patients between the ages of 18-75 years; 3) ECOG PS 0-1 points; 4) The expected survival period more than 3 months; 5) Pathologically confirmed IIIB (not suitable for radiotherapy), stage IV non-small cell lung cancer, with measurable lesions (according to RECIST 1.1, CT scan long diameter 10mm, lymph node lesion CT scan short diameter >= 15mm, The measurable lesions have not received local treatment such as radiotherapy or freezing); 6) According to any validated method, the patient has a EGFR activating mutation (exon 19 deletion or 21L858R point mutation) in primary non-small cell lung cancer; 7) Have not received chemotherapy or other targeted therapies in the past; Note: The treatment used in the neoadjuvant treatment phase is not included in the treatment plan; the recurrence within 6 months after the end of adjuvant therapy is defined as first-line treatment and cannot be included in the study; more than 6 months of recurrence, adjuvant treatment Not included in the treatment plan. ...