Association details:
| Biomarker: | EGFR mutation |
|---|---|
| Cancer: | Lung Cancer |
| Drug: | Conmana (icotinib) (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A randomized, double-blind, parallel controlled trial for Icotinib double-dose first-line therapy for EGFR 21 exon mutations in advanced non-small cell lung cancer
Excerpt:
...(1) Patients with non-small cell lung adenocarcinoma (or adenocarcinoma with initial stage IIIB/IV) that are not suitable for radical surgery or radiotherapy confirmed by pathological histology may be selected if they have been treated with adjuvant chemotherapy for more than 6 months; (2) EGFR gene detection 21 exon L858R mutation; (3) Aged 18-75 years old; (4) ECOG 0-3 points; (5) Asymptomatic brain metastasis; (6) There are imaging evaluable lesions. ...
Trial ID:
Source:
Title:
Phase II Trial of Double Dose of Icotinib in Treating Brain Metastases From Non-small Cell Lung Cancer
Excerpt:
...- Patients with EGFR mutation or the lesions that remains stable for more than 3 months after local treatment(WBRT and/or SRS) combined with Icotinib treatment....
Trial ID:
More C2 evidence
Source:
Title:
A patient with advanced non-small cell lung cancer with positive epidermal growth factor receptor (EGFR) gene sensitive mutations and brain metastases was used as a test subject to evaluate the tolerance and efficacy of ametinib combined with icotinib: single arm study
Excerpt:
...(1) Sign the informed consent form voluntarily; (2) The age at the time of signing the informed consent form greater than 18 years old; (3) Patients with stage IV non-small cell lung cancer diagnosed by histopathology or cytology; (4) Patients with asymptomatic brain metastases or symptomatic brain metastases are stable after treatment; (5) The diagnosis of brain metastasis is diagnosed by imaging examinations such as computerized tomography (CT) or nuclear magnetic resonance (MRI); (6) The detection of tumor tissue samples revealed sensitive EGFR mutations and no tyrosine kinase inhibitors targeting EGFR have been used; (7) The ECOG physical status scoring standard within 2 weeks before the first use of the study drug 0-1; (8) The expected life span greater than 3 months; (9) According to the RECIST 1.1 standard, imaging tests show that there are measurable tumor lesions in the brain and extracranium; (10) Laboratory inspection indicators meet the following standards: Neutrophil count >= 1.5x10^9/L; Platelet count >= 100x10^9/L; Hemoglobin >= 90 g/L; Creatinine clearance rate <= 1.5 ULN; The AST and ALT of patients with liver metastases <= 5 ULN, and the AST and ALT of patients without liver metastases <= 2.5 ULN; Total bilirubin <= 1.5 ULN. ...
Trial ID:
Source:
Title:
A Multicenter Prospective Study to Assess the Effects of Adjuvant Icotinib in EGFRm Stage I NSCLC With High-risk of Disease Recurrence After Complete Resection
Excerpt:
...- A tumour which harbours one of the 2 EGFR mutations (Ex19del, L858R) ,without KRAS mutation...
Trial ID:
Source:
Title:
Alternating Icotinib and Chemotherapy for Advanced Non-small Cell Lung Cancer With EGFR Mutation
Excerpt:
...Positive EGFR mutation(19 exon or 21 exon)。...
Trial ID:
Source:
Title:
Icotinib as Neoadjuvant Therapy in EGFR-mutant Stage ⅢA-N2 Non-small Cell Lung Cancer
Excerpt:
...- Histology or cytology confirmed Non-small Cell Lung Cancer; EGFR mutation (EGFR 19del and/or 21L858R) detected by tumor tissue biopsy of primary lesion or metastatic lesion or plasma ctDNA...
Trial ID:
Source:
Title:
Icotinib Following Chemotherapy Versus Chemotherapy as Adjuvant Therapy in Stage IIA-IIIA NSCLC With EGFR Mutation
Excerpt:
...- EGFR activating mutation in exon 19 or 21....
Trial ID:
Source:
Title:
Icotinib as Consolidation Therapy After Chemoradiotherapy in EGFR-Mutant Stage IIIA-IIIB Non-small Cell Lung Cancer
Excerpt:
...- Unresectable stage IIIA-IIIB Non-small Cell Lung Cancer, histology or cytology confirmed lung adenocarcinoma, pathological specimens with EGFR 19 del and/or 21 L858R gene mutation detected by amplification refractory mutation system method...
Trial ID:
Source:
Title:
Icotinib as Neoadjuvant and Adjuvant Therapy in EGFR-mutant Stage IIIB or Oligometastasis Non-small Cell Lung Cancer
Excerpt:
...- Histology or cytology confirmed Non-small Cell Lung Cancer; EGFR mutation (EGFR 19del and/or 21L858R) detected by tumor tissue biopsy of primary lesion or metastatic lesion or plasma ctDNA...
Trial ID:
Source:
Title:
Icotinib Versus Placebo as Adjuvant Therapy in EGFR-mutant Lung Adenocarcinoma
Excerpt:
...- Patients must harbor sensitive EGFR gene mutation (19/21)...
Trial ID:
Source:
Title:
Icotinib Combined With Dihydroaremisinin (DHA) Therapy in Patients With Advanced NSCLC
Excerpt:
...Sensitive EGFR gene mutation(19/21) 5....
Trial ID:
Source:
Title:
Icotinib or Whole Brain Irradiation in EGFR-mutant Lung Cancer
Excerpt:
...Patient who was confirmed stage IV NSCLC with EGFR activating mutation and brain metastases by pathologic histology or cytology....
Trial ID:
Source:
Title:
Icotinib in Non-small Cell Lung Cancer Patients With Uncommon EGFR Mutation
Excerpt:
...- Patients with uncommon epidermal growth factor receptor (EGFR) mutation...
Trial ID:
Source:
Title:
Efficacy Study of Chinese Medicine Plus EGFR-TKI Versus EGFR-TKI in Advanced Pulmonary Adenocarcinoma
Excerpt:
...Patient with mutated EGFR will subject to first line target thearapy；patients received at least one cycle platinum-containing chemotherapy regimens with disease progression/recurrence， or intolerant/refuse to proceed with chemotherapy will explore second line target therapy; 3....
Trial ID:
Source:
Title:
Icotinib Combined With WBRT For NSCLC Patients With Brain Metastases and EGFR Mutation
Excerpt:
...- Positive EGFR mutation....
Trial ID:
Source:
Title:
Icotinib concurrent thoracic radiotherapy treat for advanced non-small-cell lung cancer (NSCLC) with an activating EGFR gene mutation
Excerpt:
...Patients with stage IV non-small cell lung cancer harboring activating EGFR mutation which confirmed by histopathological or cytological examination; have at least one measurable lesion; with lesions larger than 20 mm detected by CT or MRI, or larger than 10 mm detected by PET-CT; could survival more than 3 months....
Trial ID:
Source:
Title:
A Single-arm Study to Evaluate the Efficacy of Intercalated Combination of Chemotherapy and Icotinib as First-line Treatment for Patients With Non-Small-Cell Lung Cancer
Excerpt:
...EGFR mutation-positive (EGFR exon-18, exon-19 or exon-21); 5. ...
Trial ID:
Source:
Title:
Neoadjuvant Icotinib With Chemotherapy for Epidermal Growth Factor Receptor(EGFR)-Mutated Resectable Lung Adenocarcinoma
Excerpt:
...- A tumor which harbors either Ex19del or L858R EGFR-TKI-sensitizing mutations, either alone...
Source:
Title:
A Study of Icotinib With Chemotherapy as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer
Excerpt:
...- EGFR mutation was detected by Amplification Refractory Mutation System(ARMS) and confirmed to be one of the 2 common EGFR mutations known to be associated with EGFR-TKI （epidermal growth factor receptor tyrosine kinase inhibitors）sensitivity (Ex19del, L858R)....
Source:
Title:
Icotinib for Completed Resected IB NSCLC With EGFR Mutation
Excerpt:
...- EGFR activating mutation in exon 19 or 21....
Trial ID:
Source:
Title:
Icotinib as Adjuvant Therapy Compared With Standard Chemotherapy in Stage II-IIIA NSCLC With EGFR-mutation
Excerpt:
...- Positive EGFR gene mutation (19/21)...
Trial ID:
Source:
Title:
A Study to Determine the Efficiency For Brain Metastasis NSCLC Patients Treated With Icotinib Alone or Combined With Radiation Therapy
Excerpt:
...- Positive EGFR mutation（Ex19del or 21L858R）...
Trial ID:
Source:
Title:
Icotinib Versus First-line Chemotherapy Plus Maintenance Treatment in EGFR Positive Lung Adenocarcinoma Patients
Excerpt:
...- Positive EGFR Mutation....
Trial ID:
Source:
Title:
High Dose Icotinib With Sequential SRS For NSCLC Patients Harboring EGFR Mutation With Brain Metastases
Excerpt:
...- Positive EGFR mutation（Ex19del or 21L858R）....
Trial ID:
Source:
Title:
Intermittent and Maintenance of Icotinib in Combination With Pemetrexed/Carboplatin Compared With Icotinib Single Drug in Ⅲb/IV Non Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Mutation
Excerpt:
...- Confirmed activating mutation of EGFR-ie, an exon 19 deletion or an exon 21 L858R point mutation....
Trial ID:
Source:
Title:
Efficiency of Icotinib in Plasma ctDNA EGFR Mutation-positive Patients Diagnosed With Lung Cancer
Excerpt:
...- Plasma EGFR mutations (EGFR 19del and/or 21L858R) positive (simultaneously detected by Super-ARMS, ddPCR and NGS，any positive)....
Trial ID:
Source:
Title:
High Dose Icotinib in Advanced Non-small Cell Lung Cancer With EGFR 21 Exon Mutation
Excerpt:
...- Positive EGFR 21 exon mutation or 19 exon deletion...
Trial ID:
Source:
Title:
Icotinib Combined With SBRT for Patients With Metastatic Non-squamous NSCLC With EGFR Mutation
Excerpt:
...- Histologic documentation of primary lung carcinoma, non-squamous histology with EGFR mutation....
Trial ID:
Source:
Title:
Icotinib as First-line and Maintenance Treatment in EGFR Mutated Patients With Lung Adenocarcinoma
Excerpt:
...- Pathologic confirmation of lung adenocarcinoma with measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded on CT); Patients must have previously untreated locally advanced or metastatic NSCLC; Patients must have lung cancer with a documented EGFR activating mutation (exon 19 deletion, L858R)....
Trial ID:
Source:
Title:
High-dose Icotinib Treatment Beyond Progression in EGFR Mutant NSCLC
Excerpt:
...- are EGFR mutation-positive or...
Trial ID:
Source:
Title:
First-line Icotinib With Concurrent Radiotherapy for NSCLC With EGFR Mutation
Excerpt:
...- Positive EGFR mutation confirmed by ARMS...
Trial ID:
Source:
Title:
The Role of Icotinib in the Perioperative Treatment of IIIA - IIIB NSCLC Patients With EGFR Mutation
Excerpt:
...Pathologically confirmed non-small cell lung cancer with EGFR exon 19 deletion or exon 21 L858 mutation....
Trial ID:
Source:
Title:
Conmana Combined With Thalidomide to Treat NSCLC
Excerpt:
...5 years the progression-free survival (PFS) rate of the combination of thalidomide with gefitinib in patients who harbors EGFR mutations....
Trial ID:
Source:
Title:
Intercalated Combination of Chemotherapy and Tyrosine Kinase Inhibitors as First-line Treatment for Patients With Non-Small-Cell Lung Cancer
Excerpt:
...- EGFR mutation-positive (EGFR exon-18, exon-19 or exon-21);...
Trial ID:
Source:
Title:
First-line Treatment With Icotinib in Elder NSCLC EGFR Mutated Patients
Excerpt:
...- Positive EGFR Mutation....
Trial ID:
Source:
Title:
Sequential Icotinib Plus Chemotherapy Versus Icotinib Alone as First-line Treatment in Stage IIIB/IV Lung Adenocarcinoma
Excerpt:
...- EGFR activating mutation (exon 19 deletion, L858R) is required...
Trial ID:
Source:
Title:
Icotinib With Concurrent Radiotherapy vs. Chemoradiotherapy in Non-small Cell Lung Cancer
Excerpt:
...Unresectable stage IIIA / IIIB non-small cell lung cancer with EGFR 19/21 mutation....
Trial ID:
Source:
Title:
Icotinib and Arsenic Trioxide in Treating Non-small-cell Lung Cancer Patients With Resistance to EGFR-TKI
Excerpt:
...- Histologically or cytologically confirmed stage IIIB/IV lung cancer with EGFR mutation...
Trial ID:
Source:
Title:
Icotinib as the Adjunctive Treatment After Surgery in Stage I-IIIB Lung Adenocarcinoma Patients With EGFR Gene Mutation
Excerpt:
...- Lung adenocarcinoma patients with epidermal growth factor receptor gene mutation,stage I-IIIB after surgery...
Trial ID:
Source:
Title:
Icotinib With Concurrent Radiotherapy Versus Chemotherapy With Concurrent Radiotherapy in Non-small Cell Lung Cancer
Excerpt:
...- Unresectable stage IIIA / IIIB non-small cell lung cancer with EGFR 19/21 mutation...
Trial ID:
Source:
Title:
Icotinib Combined With Whole Brain Radiotherapy in Treating Multiple Brain Metastases From Non-Small Cell Lung Cancer
Excerpt:
...- Patients with disease progression after systemic chemotherapy with two-drug combination regimens that includes a platinum agent or patients with EGFR mutation status who have...
Trial ID:
Source:
Title:
Sequential and Maintenance Icotinib Plus Chemotherapy Versus Icotinib Maintenance After Chemotherapy in Advanced NSCLC
Excerpt:
...- Positive EGFR Mutation...
Trial ID:
Source:
Title:
A randomized, controlled, double-blind study of Fuzheng Jiedu granules in combination with icotinib in the first-line treatment of EGFR-sensitive mutated advanced lung adenocarcinoma
Excerpt:
...(1) Those who meet the diagnostic criteria for primary bronchopulmonary carcinoma, histologically or cytologically confirmed as adenocarcinoma, with EGFR 21 exon L858R and EGFR 19 exon deletion mutations identified by Arm method or second generation sequencing. ...
Trial ID:
Source:
Title:
A multicenter, randomized, open-label, phase III clinical trial of Icotinib plus pemetrexed-cisplatin versus pemetrexed-cisplatin as postoperative adjuvant treatment in stage III (N1-N2) non-small cell lung cancer (NSCLC) with EGFR-sensitive mutation
Excerpt:
...Epidermal growth factor receptor( EGFR) sensitive mutation. ...
Trial ID:
Source:
Title:
Intercalated combination of chemotherapy and icotinib followed by icotinib maintenance compared with chemotherapy followed by icotinib maintenance in EGFR mutant patients with advanced Non-Small-Cell
Excerpt:
...The subjects must have received two cycles of gemcitabine (1000 mg/m2 on days 1 and 8, intravenously) plus platinum (cisplatin 75 mg/m2 on day 1, intravenously) as first line treatment, efficacy evaluated as DCR (CR+PR+SD); 2.Having obtained EGFR gene test, activating mutations in the EGFR gene; 3.Aged 18 to 75 years; 4. ...
Trial ID:
Source:
Title:
Bronchial arterial infusion in combination with take icotinib hydrochloride orally for treatment of advanced non-small cell lung cancer
Excerpt:
...EGFR genes mutation; 3. ...
Trial ID:
Source:
Title:
Phase II clinical study of autologous RAK cells combined with icotinib in the treatment of EGFR-mutated advanced non-small cell lung cancer
Excerpt:
...EGFR sensitive mutation (exon 19 deletion mutation or exon 21 L858R) detected by histology or peripheral blood; 5. ...
Trial ID:
Source:
Title:
A randomized, double-blind, parallel controlled trial for Icotinib double-dose first-line therapy for EGFR 19 exon mutations in advanced non-small cell lung cancer
Excerpt:
...EGFR gene detection 19 exon mutation; 3. ...
Trial ID:
Source:
Title:
Clinical study of Combined action of Icotinib and brain radiotherapy on EGFR-mutated non-small-cell lung cancer patients with brain metastasis
Excerpt:
...1) patient confirmed NSCLS; 2) MRI indicated that the measurable brain metastasis lesion; 3) patient with EGFR mutations; 4) aged 18 ~ 75 years old;ECOG PS 0 ~ 2 points;Life expectancy > 3 months; 5) all subjects or their guardians must sign the subject informed consent before entering the test....
Trial ID:
Source:
Title:
Treatment of Gefitinib or Icotinib in lung adenocarcinoma of stage IA with micropapillary or solid
Excerpt:
...Patients with single primary lung cancer, a full set of tumor marker tests, blood biochemistry tests and related routine blood tests, enhanced CT of the chest, CT or ultrasound of the abdomen (liver, gallbladder, pancreas, spleen, kidneys, and adrenal glands), ultrasound of the cervical and supraclavicular lymph nodes, MR of the head or CT of the head, and whole-body bone imaging were all perfected to exclude metastasis before surgery; Complete surgical resection of the tumor with guaranteed negative margins (R0), the patient's surgical approach can be lobectomy, segmental resection, wedge resection of the lung, and regional lymph node sampling;Postoperative pathologically confirmed stage I lung adenocarcinoma (according to the 8th edition of the AJCC TNM staging system for lung cancer) with micropapillary or solid-type components;and had a confirmed EGFR mutation(exon 19 deletion or exon 21 L858R);Eligible patients were between 18 and 75 years of age; had an Eastern Cooperative Oncology Group performance status (ECOG PS) score of 0 or 1....
Trial ID:
Source:
Title:
Clinical Study on Adjuvant Targeted Therapy with EGFR Mutation after Surgery for Stage IA Non-small Cell Lung Cancer
Excerpt:
...Pathologically confirmed non-small cell lung cancer (NSCLC) with standard radical lung cancer surgery (lobectomy or segmentectomy + hilar and mediastinal lymph node dissection/sampling); b. Postoperative pathological staging with high-risk pathological factors such as papillary/micropapillary/solid/mucinous components, with or without complex glandular structures in stage IA NSCLC; c. Positive ct-DNA test results after surgery and before adjuvant therapy (4 weeks post-surgery); d. Age ≥18 years and ≤75 years; e. ECOG or PS score of 0 or 1; f. The patient's primary NSCLC has classical EGFR mutations (EGFR 19 Del or 21 L858R); g. The diagnosed patient has not previously received lung cancer-related chemotherapy, radiotherapy, or targeted therapy; h. Normal function of major organs; i. Women of childbearing age or male subjects with partners of childbearing age must take effective contraceptive measures throughout the treatment period and for 6 months after the treatment period; complete postoperative recovery with no signs of tumor recurrence on imaging tests....
Trial ID:
Source:
Title:
Randomized phase III trial of icotinib combined with thoracic radiotherapy vs. icotinib alone in treatment of advanced NSCLC patients with EGFR mutation
Excerpt:
...EGFR sensitive mutations (EGFR 19 DEL or L858R); 5. ...
Trial ID:
Source:
Title:
A Randomized Controlled Clinical Study to Explore the Clinical Value of MRD Monitoring for Adjuvant Targeted Therapy
Excerpt:
...3.Preoperative detection of EGFR sensitizing mutations (exon 19 deletion or L858R mutation in exon 21) in ctDNA. ...
Trial ID:
Source:
Title:
Intercalated Combination of Icotinib and Chemotherapy as First-line Treatment for Patients With Non-Small-Cell Lung Cancer
Excerpt:
...EGFR mutation-positive (EGFR exon-18, exon-19 or exon-21); 2. ...
Trial ID:
Less C2 evidence
Source:
Title:
Evaluation of Clinical Outcomes of Icotinib in Patients With Clinically Diagnosed Advanced Lung Cancer With EGFR-Sensitizing Variants Assessed by Circulating Tumor DNA Testin
Published date:
07/21/2022
Excerpt:
The Efficiency of Icotinib in Plasma ctDNA EGFR Mutation-Positive Patients Diagnosed With Lung Cancer (CHALLENGE) trial is a prospective, multicentered, open-label, single-arm phase 2 nonrandomized clinical trial conducted...Enrolled patients were treated with oral icotinib tablets...The ORR was 52.6% (95% CI, 43.1%-61.9%). The median PFS and OS were 10.3 months (95% CI, 8.3-12.2) and 23.2 months (95% CI, 17.7-28.0), respectively, and the DCR was 84.5% (95% CI, 76.6%-90.5%).
DOI:
10.1001/jamaoncol.2022.2719
Trial ID:
