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Association details:
| Biomarker: | EGFR mutation |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | Keytruda (pembrolizumab) (PD1 inhibitor) + epacadostat (INCB024360) (IDO1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037)
Excerpt:
Patients received escalating doses of oral epacadostat (25, 50, 100, or 300 mg) twice per day plus intravenous pembrolizumab 2 mg/kg or 200 mg every 3 weeks....Among the five responders with NSCLC, three had adenocarcinoma histology, one was EGFR mutation positive, two were KRAS mutation positive…
DOI:
10.1200/JCO.2018.78.9602
Trial ID:
