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Association details:
| Biomarker: | EGFR mutation + TTF1 negative |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug Class: | EGFR inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
Thyroid transcription factor 1 (TTF-1) negativity as a predictor of unfavorable response to EGFR-TKI therapy in advanced lung adenocarcinoma patients with EGFR mutations
Published date:
08/22/2023
Excerpt:
The aim of this study was to assess the impact of TTF-1 expression on the clinical response to EGFR-tyrosine kinase inhibitor (TKI) treatment in patients with advanced LUAD....Among the patients with EGFR mutations, the TTF-1-negative subgroup had a significantly lower ORR (23.5% vs. 54.2%, p = 0.019) and DCR (58.8% vs. 89.7%, p = 0.003) compared to the TTF-1-positive subgroup.
DOI:
https://doi.org/10.1111/1759-7714.15079
