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Association details:
| Biomarker: | EGFR mutation + SYK overexpression |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug Class: | EGFR inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer
Published date:
05/15/2023
Excerpt:
...the 21 patients with high SYK expression and EGFR mutation showed a uniform therapeutic response to EGFRis, with a response rate of 100%...which is much higher than the 74.2% response rate of patients stratified by EGFR mutation alone (23 PR and 8 stable disease (SD)).
DOI:
https://doi.org/10.1038/s41392-023-01403-w
