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Association details:
Biomarker:
EGFR L861Q
Cancer:
Lung Cancer
Drug Class:
pan-HER inhibitor
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
J Thorac Oncol
Title:
Allele-specific role of ERBB2 in the oncogenic function of EGFR L861Q in EGFR-mutant lung cancers
Published date:
10/07/2020
Excerpt:
...pan-ERBB inhibitors exerted superior growth inhibitory effects on cells expressing compound L861Q/G719X mutations.
DOI:
10.1016/j.jtho.2020.09.019
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