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Association details:
| Biomarker: | EGFR L858R + EGFR T790M |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | KKI04 (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Design, Synthesis and Assessment of Novel Molecule against Drug-Resistant Dual Mutant EGFR (T790M/L858R) to Treat NSCLC
Published date:
08/08/2023
Excerpt:
Cell-based assays revealed that KKI04 inhibits the H1975 cells (T790M/L858R) with a 2.5 fold higher affinity than Osimertinib with IC50 values 2±0.5µM and 7±0.5µM, respectively...
