...(1) Aged 18 to 75 years; (2) Patients with locally advanced or metastatic NSCLC confirmed by histopathology and / or cytology; (3) The patient's EGFR has one or more of L861Q, G719X, and S768I mutations, and does not have T790M mutation, exon 19 deletion mutation, exon 20 insertion mutation, and L858R mutation; (4) ECOG physical strength score is 0, 1, or 2 points; (5) The expected survival time is> 3 months; (6) According to RECIST version 1.1, there is at least one evaluable tumor lesion; (7) Have sufficient blood system function, liver function, kidney function and coagulation function: Absolute neutrophil count >=1.5x10^9/L, platelet count >=90x10^9/L, hemoglobin >=90g/L; Total bilirubin <=1.5 ULN, alanine aminotransferase (ALT) <=2.5 ULN, aspartate aminotransferase (AST) <=2.5 ULN (total bilirubin in patients with liver metastases <=3.0 ULN, ALT<=5.0 ULN, AST<=5.0 ULN); Creatinine <=1.0 ULN, or creatinine clearance >=60mL/min (using Cockcroft-Gault method); International standardized ratio (INR) <=1.5; (8) Fertile qualified patients (male and female) must agree to use a reliable contraceptive method (hormonal or barrier method or abstinence) during the trial and at least 90 days after the last dose; female patients of childbearing age within 7 days before enrollment Blood human chorionic gonadotropin (HCG) pregnancy test must be negative; male patients cannot be sperm donated within 90 days after the first dose to the last dose; (9) All patients must be informed of the study before commencing any of the tests prescribed in this trial and voluntarily sign a written informed consent (ICF) approved by the ethics committee....