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Association details:
| Biomarker: | EGFR expression |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | LR004-VC-MMAE (Microtubule inhibitor, EGFR-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Excellent effects and possible mechanisms of action of a new antibody-drug conjugate against EGFR-positive triple-negative breast cancer
Published date:
12/09/2021
Excerpt:
LR004-VC-MMAE inhibited the proliferation of EGFR-positive TNBC cells...Moreover, LR004-VC-MMAE also killed tumor stem cells in EGFR-positive TNBC cells and impaired their tumorsphere-forming ability. In TNBC xenograft models, LR004-VC-MMAE at 10 mg/kg significantly suppressed tumor growth and achieved complete tumor regression on day 36.
DOI:
10.1186/s40779-021-00358-9
