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Association details:
| Biomarker: | EGFR expression |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | ficerafusp alfa (BCA101) (EGFR inhibitor, TGFβ inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
6339 / 15 - BCA101, a novel tumor-targeted bifunctional fusion antibody simultaneously inhibiting EGFR and TGF-β signaling with potential for durable tumor growth inhibition
Published date:
03/15/2023
Excerpt:
The combination of BCA101 and anti-PD1 antibody improved tumor inhibition in both B16-hEGFR expressing syngeneic mouse and in humanized HuNOG-EXL mice bearing human PC-3 xenograft models.
Secondary therapy:
PD1 inhibitor
