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Association details:
Biomarker:EGFR exon 20 mutation
Cancer:Non Small Cell Lung Cancer
Drug Class:Immunotherapy
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

Association of EGFR and HER-2 exon 20 mutations with distinct patterns of response to immune checkpoint blockade in non-small cell lung cancer.

Published date:
05/16/2018
Excerpt:
Compared to classic EGFR mutants, EGFR exon 20 mutants demonstrated a higher disease control rate at 6 and 12 months as well as higher ORR. Also, EGFR exon 20 mutants demonstrated significantly higher PFS (HR 0.45, p = 0.002) and OS (HR 0.2, p < 0.001)...EGFR exon 20 mutations are associated with superior outcome from immune checkpoint inhibitors compared to classic EGFR and HER-2 exon 20 mutations.
DOI:
10.1200/JCO.2018.36.15_suppl.9052